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To be able to assess dynamic modifications, three mice per arm had been sacrificed right after 4 days of therapy and tissue sections have been subjected to immunohistochemical Examination. Cure with vistusertib or vistusertib together with fulvestrant revealed suppression of pAKTSer473, p4EBP1Thr37/46 and pS6RPSer235/six, in addition to a slight